Research Interests

My research interests lie broadly in the application of simulation, optimization, and data analysis to support health care decision-making. I am currently interested in efficient learning in clinical trials, precision medicine, and health care in the intensive care unit (ICU).

Published Work

• Value-Based Clinical Trials: Selecting Trial Lengths and Recruitment Rates in Different Regulatory Contexts with S.E. Chick and M. Forster. Management Science 2022.
  • Finalist of the POMS College of Healthcare Operations Management Best Paper Competition 2021
• Resource Allocation with Sigmoidal Demands: A Data-Driven Approach to Managing Mobile Healthcare Units with P. Blaettchen, H. de Vries, and L.N. Van Wassenhove. M&SOM 2021.
• Efficient Monte Carlo methods for estimating failure probabilities with H.A. Darji, A. Imamura, M.K. Nakayama. Reliability Engineering and System Safety 2017.

Healthcare application papers

• A quality improvement study on how a simulation model can help decision making on organization of ICU wards with D. Sent, D.M. van der Meulen, S.E. Chick, I.J.A. Wissink, A.P.J. Vlaar, D.A. Dongelmans
• The Impact of Model Assumptions on Personalized Lung Cancer Screening Recommendations with K. ten Haaf, K. de Nijs, G. Simoni, P. Cao, Z. Sun, and the CISNET lung cancer group
• Cost-Effective Clinical Trial Design: Application of a Bayesian Sequential Stopping Rule to the ProFHER Pragmatic Trial with M. Forster, S. Brealey, S.E. Chick, A. Keding, B. Corbacho, and A. Rangan. Clinical Trials 2021.
• ICU Capacity Management During the COVID-19 Pandemic Using a Stochastic Process Simulation with S.E. Chick, D.A. Dongelmans, A.F. van der Sluijs, W.J. Wiersinga, A.P.J. Vlaar, and D. Sent. Journal of Intensive Care Medicine Letters 2021. Accompanying code and web application

Working Papers

• Learning Personalized Treatment Strategies with Predictive and Prognostic Covariates in Adaptive Clinical Trials with S.E. Chick and S.I. Zoumpoulis

Conference Proceedings

• Estimating Value of Information Arm Allocation Indices in Contextual Ranking and Selection Problems with S.E. Chick and S.I. Zoumpoulis. Winter Simulation Conference 2024
• Expected Value of Information Methods for Contextual Ranking and Selection: Clinical Trials and Simulation Optimization with S.E. Chick and S.I. Zoumpoulis. Winter Simulation Conference 2021
• A Simulation Model to Evaluate the Patient Flow in an Intensive Care Unit Under Different Levels of Specialization with S.E. Chick, O. Lvova, and D. Sent. Winter Simulation Conference 2020.
• Extending a Bayesian Decision-Theoretic Approach to Value-Based Sequential Clinical Trial Design with S.E. Chick and M. Forster. Winter Simulation Conference 2018.
• Variance Reduction for Estimating a Failure Probability with Multiple Criteria with H.A. Darji, A. Imamura, M.K. Nakayama. Winter Simulation Conference 2016.